Lay people, religious, deacons and priests from all over the Diocese of Westminster are expected to take part in the devotion.
The devotion, to mark the closing of the Year of the Eucharist, brings together the celebration of the Mass, the Divine Office, a Blessed Sacrament procession and the solemn blessing in Benediction.
The cardinal, who just returned from the three-week Synod of Bishops on the Eucharist, will open the Forty Hours by celebrating and preaching at Mass end it by celebrating and preaching at the vigil Mass on Saturday night.
Cardinal Murphy-O’Connor is one of the members of the postsynodal commission that will help Benedict XVI as he writes an apostolic exhortation on the synod’s themes.