The March 4-10 retreat will be held in the Redemptoris Mater chapel of the apostolic palace.
Cardinal George, 64, has led the Chicago Archdiocese since 1997. He entered the Oblates of Mary Immaculate at age 20, and was ordained to the priesthood in 1963. He became provincial superior in Minnesota for the order in 1973, and the following year moved to Rome as vicar general for the Oblates, a post he held until 1986.
He returned to the United States in 1987 as bishop of Yakima, Washington, and became archbishop of Portland, Oregon, in 1996 before being named to succeed Cardinal Joseph Bernardin in Chicago.
The offices of the Roman Curia will be closed during the week of the retreat.